Pedigree association: assigning individual weights to pedigree members for genetic association analysis
نویسندگان
چکیده
منابع مشابه
Pedigree association: assigning individual weights to pedigree members for genetic association analysis
OBJECTIVE Methods exist to appropriately perform association analyses in pedigrees. However, for genome-wide association analysis, these methods are computationally impractical. It is therefore important to determine alternate methods that can be efficiently used genome-wide. Here, we introduce a new algorithm that considers all relationships simultaneously in arbitrary-structured pedigrees and...
متن کاملPedigree Generation for Analysis of Genetic Linkage and Association
We have developed a software package, SIMLA (simulation of linkage and association), which can be used to generate pedigree data under user-specified conditions. The number and location of disease loci, disease penetrances, marker locations, and marker disequilibrium with a disease locus and with other markers can be controlled. In addition, the pedigree size and availability of genotype data m...
متن کاملPedigree Analysis for Genetic Counseling
We report on the design and implementation of a prototype program, GENINFER , to assist genetic counselors in evaluating the risk of recurrence of genetic disorders based on the analysis of family pedigrees. The present version of the program integrates a convenient graphical interface that permits counselors to draw, examine and modify family pedigrees and to enter information relevant to ri...
متن کاملA comparison of founder-only and all-pedigree-members genotype-expression association by regression analysis
Genotype-expression association analysis using linear regression may produce different test results depending on whether founders only or all pedigreed members are used. This difference is not due to the correlation of samples within a pedigree, because linear mixed models have been applied to account for that correlation. We investigated the possibility that the difference is due to a dependen...
متن کاملHierarchical linear modeling of longitudinal pedigree data for genetic association analysis
Genetic association analysis on complex phenotypes under a longitudinal design involving pedigrees encounters the problem of correlation within pedigrees, which could affect statistical assessment of the genetic effects. Approaches have been proposed to integrate kinship correlation into the mixed-effect models to explicitly model the genetic relationship. These have proved to be an efficient w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2009
ISSN: 1753-6561
DOI: 10.1186/1753-6561-3-s7-s121